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目的了解株洲市母婴麻疹IgG抗体水平及相互关系,为探索小月龄儿童麻疹防控策略提供参考依据。方法2014年4~6月采用麻疹病毒IgG抗体定量检测试剂盒(酶联免疫法)对株洲市405名产妇(抽静脉血)及405名新生儿(婴儿脐带血)进行麻疹IgG抗体检测和定量分析。结果株洲市新生婴儿IgG抗体阳性率、平均抗体浓度(GMC)分别为62.96%(255/405)、680.01mIU/ml,其中具有母源麻疹抗体完全保护水平(抗体浓度≥1 000mIU/ml)的新生儿仅占26.42%;母亲麻疹IgG抗体阳性率、GMC分别为52.59%(213/405)、573.93mIU/ml,母亲麻疹抗体水平以低浓度为主,占66.91%,具有麻疹抗体完全保护水平的母亲仅占17.28%;母婴麻疹抗体浓度相关系数为0.40,婴儿抗体水平随母亲的增高而增高(Spearman等级相关,rs=0.36,P<0.01)。结论母亲麻疹抗体水平的高低是影响婴儿母源麻疹抗体水平的重要因素。株洲市母婴麻疹抗体保护水平低。
Objective To understand the relationship between maternal and measles IgG antibodies in Zhuzhou and to provide a reference for exploring the prevention and control strategies for measles in children with small months. Methods From April to June 2014, measles IgG antibody was detected and quantified in 405 mothers (pumped venous blood) and 405 newborns (infant cord blood) in Zhuzhou City by using the quantitative detection kit of measles virus IgG (enzyme-linked immunosorbent assay) analysis. Results The positive rate and mean antibody concentration (GMC) of neonatal infant IgG in Zhuzhou City were 62.96% (255/405) and 680.01 mIU / ml, respectively, with the complete protection of maternal measles antibody (antibody concentration ≥1 000 mIU / ml) The newborn accounted for only 26.42%; the positive rate of maternal measles IgG antibody was 52.59% (213/405) and 573.93mIU / ml respectively, while the level of maternal measles antibody was low (66.91%), with a measles antibody level of complete protection Of the mothers accounted for only 17.28%. The correlation coefficient of maternal and measles antibody concentration was 0.40. The level of infant antibody increased with the increase of mothers (Spearman rank correlation, rs = 0.36, P <0.01). Conclusion The level of maternal measles antibody is an important factor affecting the maternal measles antibody level in infants. Zhuzhou City, maternal and child measles antibody protection level is low.