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作者在中国台湾省,将HBsAg和HBeAg均阳性的母亲所生的108名婴儿,随机分成3组,均于出生后第2、6和10周及1年时分别接种5μg乙型肝炎病毒(HBV)疫苗.第1组只接种疫苗;第2组还于出生时增加注射乙型肝炎免疫球蛋白(HBIG);第3组于出生及1个月时注射HBIG.为测定低剂量HBV疫苗的免疫原性和效能,对HBsAg和HBeAg均阳性的母亲所生的50名婴儿(第4组),于出生后第1、5周及第6个月接种2.5μgHBV疫苗,并于出生时注射HBIG.另外,对HBsAg阳性、HBeAg阴性母亲所生的婴儿,于第1、5和9周及1年时接种5μg HBV疫苗.14个月的随访结果表明,第1组HBsAg阳性率为19.4%(7/36);第2组为11.4%(4/35);第3组为8.1%(3/37);对照组为78.4%(40/51);第4组为10.0%(4/40).接种后各组保护率分别为:第1组为75.3%,第2组85.5%,第3组89.7%,第4组87.2%.
In Taiwan Province of China, 108 infants born to HBsAg and HBeAg-positive mothers were randomized into 3 groups, each of which was inoculated with 5 μg of Hepatitis B virus (HBV) at 2, 6 and 10 weeks and at 1 year Group 1 received only vaccination, Group 2 also received an additional injection of HBIG at birth, Group 3 received HBIG at birth and at 1 month, and in order to determine the immunization of low-dose HBV vaccine 50 babies (Group 4) born to mothers who were both positive for HBsAg and HBeAg were vaccinated with 2.5 μg of HBV vaccine at weeks 1, 5, and 6 postnatal and were given HBIG at birth. In addition, infants born to HBsAg-positive, HBeAg-negative mothers were vaccinated with 5 μg of HBV vaccine at weeks 1, 5, and 9 and at 1 year.14 months of follow-up showed that the HBsAg positive rate in group 1 was 19.4% (7 / 36 in group 2), 11.4% (4/35) in group 2, 8.1% (3/37) in group 3, 78.4% (40/51) in control group, and 10.0% (4/40) in group 4 After inoculation, the protective rates of each group were 75.3% in the first group, 85.5% in the second group, 89.7% in the third group and 87.2% in the fourth group.