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本文应用放射免疫分析方法测定了急性淋巴细胞白血病患儿血清β_2微球蛋白(sβ_2mG),结果表明;初治患儿sβ_2mG值升高,完全缓解时,sβ_2mG值降至正常水平;高危型比普通型患儿sβ_2mG值高;初治患儿sβ_2mG值与外周血中幼稚淋巴细胞数、骨髓中原始幼稚淋巴细胞百分数均呈正相关。提示急淋患儿sβ_2mG值的变化与病情和预后关系密切,有可能做为监测病情变化、观察化疗疗效和判断预后的客观指标。
In this paper, we measured the serum β_2 microglobulin (sβ_2mG) in children with acute lymphoblastic leukemia by radioimmunoassay. The results showed that the sβ_2mG value of children with primary lymphocytic leukemia increased, and the level of sβ_2mG decreased to normal level in the complete remission. The sβ_2mG value of children with type II was high. The sβ_2mG value of the newly diagnosed children was positively correlated with the number of naive lymphocytes in peripheral blood and the percentage of naive lymphocytes in bone marrow. The results suggest that the change of sβ_2mG in children with acute lymphocytic leukemia is closely related to the disease and prognosis, which may be used as an objective indicator to monitor the change of the disease and observe the curative effect of chemotherapy and prognosis.