严重脓毒症和感染性休克仍是危重患者最主要的死因之一,近30年来病死率呈上升趋势,G+菌所致感染性休克明显增多,混合感染也在增加[1]。其确切致死原因尚未明了,一般认为对儿茶酚胺耐药的低血压和脓毒症时心肌抑制是主要死因[2]。而心肌细胞膜β肾上腺素能受体(-βAR)发挥了主要 Severe sepsis and septic shock are still one of the most important causes of death in critically ill patients. The mortality rate has been on the rise in the past 30 years. The number of septic shock caused by G + bacteria is significantly increased, and mixed infections are also increasing [1]. The exact cause of death is not yet clear, generally considered catecholamine-resistant hypotension and myocardial infarction in sepsis is the leading cause of death [2]. Myocardial membrane beta adrenergic receptor (-βAR) play a major role