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目的了解前S1蛋白(PreS1)、乙型肝炎病毒(HBVDNA)及丙氨酸氨基转移酶(ALT)与急性乙型肝炎(AHB)病程的关系。方法采用酶联免疫吸附试验(ELISA)、核酸扩增(PCR)荧光定量检测技术和双试剂法分别检测PreS1抗原、HBVDNA和ALT。结果不同病程AHB患者血清PreS1抗原与ALT阳性符合率较高(P>0.05),HBVDNA与ALT相比阳性符合率较低(P<0.01)。结论AHB患者治疗过程中,PreS1抗原与ALT阴转基本一致,先于HBVDNA阴转,提示疾病的转归及预后较好。
Objective To investigate the relationship between PreS1, HBVDNA and alanine aminotransferase (ALT) and the course of acute hepatitis B (AHB). Methods The PreS1 antigen, HBVDNA and ALT were detected by enzyme-linked immunosorbent assay (ELISA), nucleic acid amplification (PCR) fluorescence quantitative detection and double reagent method respectively. Results The positive rates of PreS1 antigen and ALT in AHB patients with different course of disease were higher (P> 0.05). The positive coincidence rate of HBVDNA with ALT was lower (P <0.01). Conclusions PreS1 antigen is basically the same as the negative conversion of ALT during the course of treatment of AHB patients, which is negative before HBVDNA, suggesting that the prognosis and prognosis of the disease are good.