论文部分内容阅读
目的分析静脉血栓栓塞症(VTE)住院患者的患病情况、临床特征和危险因素。方法回顾性分析北京协和医院1994年至2004年住院 VTE 病例的患病趋势、人口学特点、获得性及遗传性危险因素。结果共收集 VTE 患者672例,男:女=1.2:1,中位年龄53(14～92)岁。初发患者580例(86.3%),发病高峰年龄男性患者为40～50岁,女性为50～60岁。主要获得性危险因素有抗磷脂抗体阳性(32.0%)、外伤和(或)手术(31.1%)、肿瘤(17.1%)。其中具有多种获得性危险因素者占35.7%。94例患者在抗凝治疗前取外周血检测了蛋白 C(PC)、蛋白 S(PS)和抗凝血酶(AT)活性。抗凝蛋白总缺陷率为44.7%,以 PC 缺乏以及 PC 与 AT 联合缺乏为主,分别占13.8%和10.6%。同时具有遗传和获得性危险因素者占31.6%。结论研究结果显示综合医院的住院 VTE 病例数呈逐年上升趋势,男性 VTE 患者的初发年龄较女性提早约10年。主要获得性危险因素为抗磷脂抗体阳性、外伤或手术和肿瘤,而遗传性危险因素则以 PC 缺乏和 PC 与 AT 联合缺乏为主。多种危险因素并存是促发 VTE 的重要原因。
Objective To analyze the prevalence, clinical characteristics and risk factors of hospitalized patients with venous thromboembolism (VTE). Methods The prevalence trends, demographic characteristics, acquired and hereditary risk factors of hospitalized VTE cases from 1994 to 2004 in Peking Union Medical College Hospital were analyzed retrospectively. Results A total of 672 VTE patients were collected, with a male to female ratio of 1.2 to 1 and a median age of 53 to 14 years. The initial onset of patients 580 cases (86.3%), peak incidence age male patients 40 to 50 years of age, women 50 to 60 years. The main acquired risk factors were antiphospholipid antibody positive (32.0%), trauma and / or surgery (31.1%) and tumor (17.1%). Among them, 35.7% had multiple acquired risk factors. Ninety-four patients tested for protein C (PC), protein S (PS) and antithrombin (AT) activity before taking anticoagulant therapy. The total defect rate of anticoagulant protein was 44.7%, which was mainly PC deficiency and combined lack of PC and AT, accounting for 13.8% and 10.6% respectively. At the same time with genetic and acquired risk factors accounted for 31.6%. Conclusions The results of the study showed that the number of hospitalized VTE cases in general hospitals has been increasing year by year. The onset age of male VTE patients is about 10 years earlier than that of women. The main acquired risk factors were antiphospholipid antibody positive, trauma or surgery and tumor, while the genetic risk factors were PC deficiency and combined PC and AT deficiency. A variety of risk factors coexist is an important cause of VTE.