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本文采用放射免疫法分别检测了２２例过敏性紫癜患儿和１９例正常儿童血浆内皮素浓度改变。其中单纯皮肤性紫癜７例，混合性紫癜８例，紫癜性肾炎７例。结果：单纯性紫癜血浆内皮素浓度为３７．３４±１４．０３ｐｇ／ｍｌ与对照组的３６．２３±１２．５１ｐｇ／ｍｌ比较无明显差异（Ｐ＞０．５０），混合型紫癜患儿血浆内皮素浓度为５３．１０±１４．５１ｐｇ／ｍｌ高于对照组和单纯紫癜组（Ｐ均＜０．０５），紫癜性肾炎血浆内皮素浓度明显增高达７７．７７±１２．４４ｐｇ／ｍｌ，显著高于对照组和单纯型与混合型紫癜患者（Ｐ均＜０．０１）。提示：血浆内皮素浓度增高与本病严重程度成正比，内皮素参与了混合性紫癜尤其是紫癜性肾炎发病过程。
In this paper, radioimmunoassay were detected in 22 cases of children with Henoch-Schonlein purpura and 19 cases of normal plasma endothelin concentration changes. Of which pure skin purpura in 7 cases, 8 cases of mixed purpura, purpura nephritis in 7 cases. Results: Purpura plasma endothelin concentration of 37.34 ± 14.03pg / ml compared with the control group 36.23 ± 12.51pg / ml no significant difference (P> 0.50), mixed purpura in children with plasma Endothelin concentration was 53.10 ± 14.51pg / ml higher than the control group and pure purpura group (all P <0.05), purpura nephritis plasma endothelin concentration was significantly increased 77.77 ± 12.44pg / ml, Which were significantly higher than those in control group and pure and mixed type purpura (all P <0.01). Tip: plasma endothelin concentration increases in proportion to the severity of the disease, endothelin is involved in the mixed purpura, especially the pathogenesis of purpura nephritis.