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目的探讨热毒宁注射液佐治儿童甲型H1N1流感合并肺炎的临床疗效。方法将2009年12月至2010年2月南京医科大学附属南京儿童医院78例甲型H1N1流感合并肺炎患儿随机分为两组,其中治疗组40例,对照组38例。两组均采用常规治疗方法(口服奥司他韦,细菌感染者加用抗生素,以及对症支持治疗),治疗组加用热毒宁注射液(0.5mL/kg,每日1次,疗程7d)。结果治疗组在退热时间、咳喘消失时间、肺部啰音消失时间、X线胸片吸收时间、住院天数方面均优于对照组(P均<0.05)。总有效率治疗组为97.5%,对照组为84.2%,两组比较差异有统计学意义(P<0.05)。结论热毒宁注射液可明显提高常规治疗儿童甲型H1N1流感合并肺炎的疗效。
Objective To investigate the clinical efficacy of Reveduning Injection in children with influenza A (H1N1) and pneumonia. Methods From December 2009 to February 2010, 78 children with influenza A (H1N1) pneumonia in Nanjing Children’s Hospital Affiliated to Nanjing Medical University were randomly divided into two groups, 40 in the treatment group and 38 in the control group. The two groups were treated with conventional treatment (oral oseltamivir, bacterial infection plus antibiotics, and symptomatic supportive treatment), the treatment group with heat poisoning injection (0.5mL / kg, once daily for 7 days) . Results The treatment group was better than the control group in the time of antipyretic, the disappearance of cough and asthma, the disappearance of pulmonary rales, the time of X-ray absorption and the days of hospitalization (all P <0.05). The total effective rate was 97.5% in the treatment group and 84.2% in the control group, with significant difference between the two groups (P <0.05). Conclusion Revedun injection can significantly improve the efficacy of routine treatment of children with influenza A (H1N1) and pneumonia.