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通过亲代雌性小鼠在一定时期内自由饮用200mg/L含氟水,使母鼠血氟浓度增高.借助组织形态学方法和放射免疫分析法观察母鼠受高氟因素作用对子代甲状腺形态、功能以及对胚胎甲状腺发生过程的影响.结果表明:母鼠受孕后开始受氟化物作用,其胎(仔)鼠血甲状腺素(T_4)水平和甲状腺滤泡细胞增高度(H)均显著高于正常对照组;亲代母鼠孕前度及孕期长期慢性氟暴露,其胎(仔)鼠在部分取材时间内其T_4和H与对照组有差别,但其变化无明显规律;氟对胚胎甲状腺的发生发育在时间上无明显延迟作用,仅使部分腺体的滤泡成熟次序发生改变.上述结果提示:母体氟暴露对子代甲状腺存在一定的不良影响.
The blood fluoride level in maternal mice was increased by drinking 200 mg / L fluoride-free water in the female mice for a certain period of time.Through histomorphometry and radioimmunoassay, the effects of high fluoride on the thyroid morphology, Function and the effect on the process of embryo thyroid gland formation.The results showed that after the conception of the mother rats began to be affected by fluoride, the level of thyroid hormone (T_4) and thyroid follicular cells increased (H) The normal control group; the prenatal degree of the parental mothers and the long-term chronic fluorosis exposure during the pregnancy. The T_4 and H of the fetus were different from those of the control group in the part of the time, but there was no obvious change. The incidence of thyroid Development in the time without significant delay in the role of only part of the gland follicular maturation sequence changes.The above results suggest that: the mother of fluoride exposure on behalf of the thyroid there is some adverse effects.