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目的观察术中继续应用Lipo PGE1对先心病伴肺高压的疗效。方法 180例随机分成三组,即对照组、试验A组及试验B组,监测三组心率(HR)变化,停循环前测左心室射血分数(EF)、肺动脉平均压(MPAP)。结果术前、中用药HR、EF差异无统计学意义,MPAP差异有统计学意义,术前用药时,MPAP已显著降低,术中继续用药,MPAP下降更明显。结论 Lipo PGE1扩张肺血管有较好的作用,术中继续应用效果更好。
Objective To observe the effect of continuous application of Lipo PGE1 on pulmonary hypertension in patients with congenital heart disease. Methods One hundred and eighty cases were randomly divided into three groups: control group, experimental group A and B group. HR changes, left ventricular ejection fraction (EF) and mean pulmonary artery pressure (MPAP) were measured before stopping circulation. Results There was no significant difference in HR and EF before and after medication. There was a significant difference in MPAP between the two groups. Preoperative medication, MPAP had been significantly reduced. Conclusions Lipo PGE1 has a good effect on the expansion of pulmonary blood vessels and continues to be used more effectively during operation.