Dear Editor,rnBipolar disorder (BD) is a chronic and disabling disorder characterized by manic,hypomanic,or depressive episodes,with an estimated lifetime prevalence ranging from 1％ to 5％.Globally,it is a leading cause of disability and a socioeconomic burden.Gene-environment interactions are thought to be involved in the neurobiology of BD,with genetic factors contributing to 60％-85％ of BD patients.