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目的探讨血清内脂素(Visfantin)、脂联素(APN)和C-反应蛋白(CRP)与冠状动脉病变的关系。方法70例经冠状动脉造影确诊的冠状动脉粥样硬化性心脏病(冠心病)患者作为观察组,并根据血管病变情况分为单支病变组、双支病变组、多支病变组,另选20例健康体检者作为对照组,采用酶联免疫吸附试验测定血清Visfantin、APN、CRP水平,比较不同程度病变者血清Visfantin、APN、CRP的差异及其与冠状动脉病变的相关性。结果观察组血清Visfantin、CRP水平均显著高于对照组(P<0.01),APN水平显著于低于对照组(P<0.01)。双支病变组和多支病变组血清CRP、Visfantin水平及Gensini积分均明显高于单支病变组(P<0.05);多支病变组血清Visfantin、CRP水平及Gensini积分显著高于双支病变组(P<0.05)。双支病变组和多支病变组的APN水平均低于单支病变组(P<0.05),但双支病变组和多支病变组比较差异无统计学意义(P>0.05)。血清Visfantin与CRP(r=0.929,P<0.001)、Gensini积分(r=0.777,P<0.001)呈正相关,与APN(r=-0.351,P<0.001)呈负相关;APN与CRP(r=-0.873,P<0.001)、Gensini积分(r=-0.740,P<0.001)呈负相关;CRP与Gensini积分呈正相关(r=0.692,P<0.001)。结论血清Visfantin、APN、CRP均可能是冠心病的危险因素,对评估冠状动脉病变程度有重要价值。
Objective To investigate the relationship between serum visfatin, adiponectin (APN) and C-reactive protein (CRP) and coronary artery lesions. Methods Seventy patients with coronary atherosclerotic heart disease (CHD) confirmed by coronary angiography were selected as the observation group and were divided into single vessel disease group, double vessel disease group and multivessel disease group according to the vascular disease. Serum Visfantin, APN and CRP levels were measured by enzyme linked immunosorbent assay in 20 healthy volunteers. The differences of serum Visfantin, APN and CRP levels and coronary artery lesion were compared between the two groups. Results The levels of Visfantin and CRP in the observation group were significantly higher than those in the control group (P <0.01). The levels of APN in the observation group were significantly lower than those in the control group (P <0.01). The levels of serum CRP, Visfantin and Gensini in patients with double-vessel disease and multi-vessel disease were significantly higher than those in patients with single vessel disease (P <0.05). Visfantin, CRP levels and Gensini scores in patients with multi-vessel disease were significantly higher than those with double-vessel disease (P <0.05). The levels of APN in double-vessel disease group and multi-vessel disease group were lower than those in single vessel disease group (P <0.05), but there was no significant difference between double-vessel disease group and multi-vessel disease group (P> 0.05). Serum Visfantin was positively correlated with CRP (r = 0.929, P <0.001), Gensini score (r = 0.777, P <0.001) and negatively correlated with APN -0.873, P <0.001), Gensini score (r = -0.740, P <0.001). CRP was positively correlated with Gensini score (r = 0.692, P <0.001). Conclusion Serum Visfantin, APN and CRP may be risk factors of coronary heart disease, which is of great value in assessing the degree of coronary artery disease.