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里杜霉素(Lividomyoin)是一种新的氨基糖甙类广谱抗菌素。它是我国1973年由广西农科院自海南岛土壤中分离引出的一种放线菌,从其滤液中取得里杜霉素,由梧州制药厂生产,1977年供临床试用,梧州制药厂生产的硫酸里杜霉素为白色粉末,易溶于水,微溶于醇,不溶于有机溶剂,PH6～7.5,硫酸里杜霉素对G~-及G~+细菌有抗菌作用。初步的药理试验无延迟毒性反应里杜霉素的LD_(50)为207.5±23mg/kg。 1977年起经上海、广州、广西11间医院临床用以治疗内外儿五官科疾病35种共309例,收到较好的疗效,总有效率为82.2％,现报告如下:
Lividomyoin is a new aminoglycoside broad-spectrum antibiotic. It is our country in 1973 by the Guangxi Academy of Agricultural Sciences from the soil of Hainan Island separated from the actinomycetes, obtained from the filtrate of ridrelin, produced by Wuzhou Pharmaceutical Factory, for clinical trials in 1977, Wuzhou Pharmaceutical Factory production The ridulin sulfate is a white powder, soluble in water, slightly soluble in alcohol, insoluble in organic solvents, PH6 ~ 7.5, and rifamycin sulfate has an antibacterial effect on G ~ - and G ~ + bacteria. The preliminary pharmacological test showed that the LD50 of rivuccin was 207.5 ± 23 mg / kg without delay. Since 1977, Shanghai, Guangzhou and Guangxi 11 clinics to treat 35 cases of internal and external ENT diseases, a total of 309 cases, received a good effect, the total effective rate was 82.2%, are as follows: