用兔眼球结膜体外细胞培养和活体兔结膜下埋线并分别用喜树硷和５－氟服嘧啶对埋线周围成纤维细胞的增殖进行抑制实验。结果证明，喜树硷无论在体内还是在体外，实验组与空白对照组相比，均有显著的抑制成纤维细胞增生的作用（Ｐ＜０．０１）。体内实验组与５－氟脲嘧啶组相比，效果差异无显著性。但喜树硷所致的局部组织反应较５－氟脲嘧啶组轻，且对眼组织无毒副作用。 In vitro culture of rabbit conjunctiva and implantation of subconjunctiva in living rabbits were performed. The inhibition of proliferation of fibroblasts around embeddings was observed using camptothecin and 5-fluoropyrimidine, respectively. The results showed that, both in vivo and in vitro, the experimental group had significant inhibition of fibroblast proliferation compared with the control group (P<0.01). There was no significant difference in effect between the in vivo experimental group and the 5-fluorouracil group. However, the local tissue reaction caused by camptothecin was lighter than 5-fluorouracil group, and had no toxic or side effects on the eye tissue.