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目的研究血清电解质及尿比重、p H值与上尿路结石的相关性,初步探讨高校男性青年教师结石的发病相关因素。方法回顾性分析2006年7月-2014年10月因上尿路结石住院治疗的153例高校男性青年教师临床资料,另选206例健康体检资料作为对照,比较两者血清钾(K)、钠(Na)、氯(Cl)、钙(Ca)、二氧化碳结合力(CO2-CP)、尿比重(SG)和p H值的差异,并构建Logistic回归方程。结果与对照组相比,结石组血清钾和尿p H值明显偏低,而血清钠、氯、钙和尿比重明显偏高。经过Logistic回归后得到高校男性青年教师上尿路结石的风险方程Y=exp(-115.05-2.53×K+0.29×Na+5.20×Ca-1.14×p H+74.69×SG)/[1+exp(-115.05-2.53×K+0.29×Na+5.20×Ca-1.14×p H+74.69×SG)]。结论血清钾、钠、钙、p H值和尿比重可能参与上尿路结石的发生过程。风险方程的应用有助于该疾病的个体化防治。
Objective To study the correlation between serum electrolytes and urinary specific gravity, p H value and upper urinary tract calculi, and to explore the related factors of the incidence of stone among young male teachers in colleges and universities. Methods A retrospective analysis of clinical data of 153 male college freshmen admitted to hospital due to upper urinary tract calculi from July 2006 to October 2014 was performed. Another 206 health examination data were selected as control. The serum potassium (K), sodium (Na), chloride (Cl), calcium (Ca), carbon dioxide binding capacity (CO2-CP), urine specific gravity (SG) and p H values. Logistic regression equation was constructed. Results Compared with the control group, the serum potassium and urine p H values in the stone group were significantly lower, while the serum sodium, chloride, calcium and urine specific gravity were significantly higher. After logistic regression, the risk equation of upper urinary tract calculi of young male college teachers was obtained: Y = exp (-115.05-2.53 × K + 0.29 × Na + 5.20 × Ca-1.14 × p H + 74.69 × SG) / [1 + exp -115.05-2.53 × K + 0.29 × Na + 5.20 × Ca-1.14 × p H + 74.69 × SG)]. Conclusion Serum potassium, sodium, calcium, p H value and urinary specific gravity may be involved in the process of upper urinary tract calculi. The application of the risk equation contributes to the individual control of the disease.