大约三十年前,S.M.McCann教授发现,给大白鼠静脉注射肾上腺素后,肾上腺抗坏血酸的含量明显减少;尔后的实验进一步推测,肾上腺素兴奋肾上腺皮质功能的作用地点可能在下丘脑。 本文作者通过对外颈静脉内预先置入硅胶导管的大白鼠,静脉注射肾上腺素,观察血浆中ACTH含量的改变,以期进一步了解肾上腺素影响肾上腺皮质功能的机理。实验在两组动物中进行,即正中隆起损伤组和假损伤组,其目的在于深入探讨肾上腺素影响ACTH分泌的作用地点。 About thirty years ago, Professor S.M. McCann found that epinephrine was significantly reduced in rats after intravenous injection of epinephrine. Later experiments further suggested that the adrenaline-stimulated adrenal cortex may function in the hypothalamus. In this study, we injected intravenous epinephrine into the external jugular vein of rats, and observed the changes of ACTH content in the plasma to further understand the mechanism of adrenaline on adrenocortical function. The experiment was performed in two groups of animals, namely the median hump injury group and the sham injury group, the purpose of which is to investigate in depth the site of action of epinephrine on ACTH secretion.