论文部分内容阅读
目的初筛不同年龄组hrHPV阳性标本,同时行HPV亚型分析及液基细胞学检查,了解银川地区HPV感染基因型分布情况,探讨不同卫生资源条件下的宫颈癌筛查策略。方法选取妇科就诊16~70岁女性1 874名,采用新柏氏液基细胞学技术、HC2及HPV导流杂交分型等方法对宫颈刷出物进行检验,对细胞学异常者召回行阴道镜检查。结果 HC2初筛阳性率为16.21%,液基细胞学异常率为6.1%,HPV 16型为最常见的HPV感染型别,感染率为7.8%,HPV阳性率和HPV 16型阳性率均与细胞学病变级别呈正相关性(r为0.253、0.226,P<0.05)。结论 HPV核酸检测对宫颈癌的筛查效率高于液基细胞学。HPV亚型分析与HC2在宫颈癌筛查敏感性方面差异无统计学意义,但HC2具备操作简便、筛查成本低等优点,不失为为宫颈癌筛查的首选方法,特别是在卫生资源相对欠缺地区。
Objective To screen hrHPV positive specimens from different age groups and analyze the subtypes of HPV subtype and liquid cytology at the same time to understand the distribution of HPV genotypes in Yinchuan and to explore the screening strategies of cervical cancer under different health resources. Methods A total of 1 874 women aged 16-70 years were enrolled in this study. Cervical brushing was tested by neo-Burwell’s liquid-based cytology, HC2 and HPV diversion typing, and colposcopy was retrospectively reviewed. . Results The positive rate of HC2 in primary screening was 16.21%, and the rate of liquid-based cytology was 6.1%. HPV16 was the most common type of HPV infection and the infection rate was 7.8%. The positive rates of HPV and HPV16 were both The grade of lesions was positively correlated (r = 0.253,0.226, P <0.05). Conclusion The screening efficiency of HPV nucleic acid in cervical cancer is higher than liquid-based cytology. HPV subtype analysis and HC2 in screening sensitivity of cervical cancer was not statistically significant, but HC2 has the advantages of simple operation, low screening costs, after all, is the preferred method of screening for cervical cancer, especially in the relative lack of health resources area.