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目的:探讨肺表面活性物质(PS)预防新生儿呼吸窘迫综合征(NRDS)的疗效。方法:将2008年1月～2012年8月住院治疗胎龄<32周,体重<1 500 g的60例早产儿随机分为治疗组和对照组。两组均给予对症支持治疗,其中治疗组在此基础上给予PS进行治疗。观察两组患儿NRDS发生率、机械通气率、用氧时间,72 h内血气分析改善情况等。结果:治疗组在NRDS、机械通气例数、比例均明显低于对照组,差异均有明显的统计学意义(P<0.01),并且总用氧时间明显短于对照组,差异有明显的统计学意义(P<0.01),并且血气分析改善情况明显优于对照组。结论:对早产儿应用PS可降低NRDS发生率,值得临床推广应用。
Objective: To investigate the efficacy of pulmonary surfactant (PS) in preventing neonatal respiratory distress syndrome (NRDS). Methods: From January 2008 to August 2012, 60 preterm infants with gestational age <32 weeks and body weight <1 500 g were randomly divided into treatment group and control group. Symptomatic supportive treatment was given to both groups, of which the treatment group was given PS for treatment. The incidence of NRDS, mechanical ventilation rate, oxygen time, blood gas analysis within 72 hours in both groups were observed to improve the situation. Results: In the treatment group, the NRDS, the number of mechanical ventilation and the proportion were significantly lower than the control group, the differences were statistically significant (P <0.01), and the total oxygen time was significantly shorter than the control group, the difference was statistically significant Significance (P <0.01), and blood gas analysis was significantly better than the control group. Conclusion: The application of PS in preterm infants can reduce the incidence of NRDS, which is worthy of clinical application.