动脉粥样硬化症是严重危害人类健康的疾病之一。几十年来,各国学者对此病的病因、发病机制及药物治疗等方面作了大量研究。目前有关此病的病因和发病机制的学说纷纭。但一般都赞同:脂质特别是胆固醇代谢的障碍与动脉粥样硬化的发生有密切关系。下述的事实便说明了这一点。(1)动脉粥样硬化斑块中含大量胆固醇及其它脂质;(2)用喂胆固醇及其它能升高血胆固醇的物质的方法,能使某些实验动物例如家兔和鸟类(鸡和鸽)产生与人的动脉粥样硬化十分相似的病变;(3)高胆固醇血症病人如家族性 Atherosclerosis is one of the diseases that seriously endanger human health. For decades, scholars from various countries made a great deal of researches on the etiology, pathogenesis and drug treatment of the disease. There are different theories on the etiology and pathogenesis of this disease. But generally agree: lipid disorders, especially cholesterol metabolism and atherosclerosis are closely related. The following facts illustrate this point. (1) atherosclerotic plaque contains a large amount of cholesterol and other lipids; (2) feeding cholesterol and other substances that increase blood cholesterol can make some experimental animals such as rabbits and birds (chicken And pigeons) produce lesions very similar to human atherosclerosis; (3) patients with hypercholesterolemia such as familial