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探讨 1、6二磷酸果糖 (FDP)治疗新生儿缺氧缺血性脑病 (HIE)的疗效及预后。应用 FDP治疗了 5 2例 HIE患儿 ,剂量 2 5 0 mg/ kg/ d,半小时内静脉滴入 ,每日1次 ,7天 1疗程 ,轻者用 1疗程 ,重者用 2疗程。结果表明 :临床疗效治疗组有效率48/ 5 2 (92 .3% ) ,对照组有效率 30 / 40 (75 % ) ,两组有显著性差异 P <0 .0 5。患儿满 30天查脑电图及头颅 CT复查 ,治疗组异常率分别为 10 / 5 0 (2 0 % ) ,6 / 5 0(12 % ) ;对照组分别为 16 / 37(4 3.2 % ) ,10 / 37(2 7% ) ,两组均有显著性差异 P <0 .0 5。随防 6～ 36月 ,两组后遗症发生率分别为 4/ 35 (11.4% )、9/ 30 (30 % ) ,有显著性差异 (P <0 .0 5 )结论 :外源性 FDP能显著改善 HIE患儿临床症状、脑电图及头颅CT的恢复 ,改善预后 ,减少后遗症发生
To investigate the efficacy and prognosis of fructose 1,6 diphosphate (FDP) in neonates with hypoxic-ischemic encephalopathy (HIE). Fifty-two children with HIE were treated with FDP at a dose of 250 mg / kg / d for intravenous infusion within half an hour once daily for 7 days and 1 treatment. The results showed that the effective rate was 48/52 (92.3%) in the treatment group and 30/40 (75%) in the control group, with significant difference between the two groups (P <0.05). The children underwent encephalgraphy and cranial CT examination after 30 days. The abnormal rates in the treatment group were 10/50 (20%) and 6/50 (12%), respectively. The control group was 16/37 ) And 10/37 (27%) respectively. There was a significant difference between the two groups (P <0.05). With anti-6 to 36 months, the incidence of sequelae of the two groups were 4/35 (11.4%) and 9/30 (30%) respectively, with significant difference (P0.05). Conclusion: The exogenous FDP can be significantly Improve the clinical symptoms of HIE children, EEG and head CT recovery, improve prognosis and reduce the occurrence of sequelae