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赛克利嗪(Cyclizine)是一种新的止恶心和止吐药,它与麦角胺同时服用,可抑制因治疗偏头痛综合征时使用麦角胺而产生呕吐的副作用,还可用于治疗妊娠呕吐和眩晕。目前,对复方片剂中酒石酸麦角胺(Ⅰ)和盐酸赛克利嗪(Ⅱ)的含量测定还没有有效的分析方法。本文作者提出了反相HPLC的测定方法,并且对流动相中乙腈百分含量、pH和离子强度进行了研究。实验方法色谱柱为反相C_(18)(5μ)(250mm×4.6 mm i.d)聚合柱。流动相:乙腈:
Cyclizine is a new anti-nausea and antiemetic drug which, taken in combination with ergotamine, suppresses the side effects of vomiting induced by ergotamine in the treatment of migraine syndrome and is also useful in the treatment of emesis and dizziness. At present, there is no effective analytical method for the determination of ergotamine tartrate (Ⅰ) and hydrocodone hydrochloride (Ⅱ) in compound tablets. The authors proposed a method for the determination of reversed-phase HPLC, and investigated the percentage of acetonitrile, pH and ionic strength in the mobile phase. Experimental Method The column was a reversed-phase C 18 (5μ) (250 mm × 4.6 mm i.d) polymerization column. Mobile phase: Acetonitrile: