论文部分内容阅读
以高纯度天然亚油酸为原料,通过碱催化异构化反应制得一种阴离子可聚合脂质——共轭亚油酸钠。在水溶液中使共轭亚油酸钠分子自组装成球状胶束,再经自由基引发剂引发胶束内部共轭亚油酸钠分子间自交联反应,最终获得共轭亚油酸钠的球状自交联胶束。探索了引发剂种类和用量、反应时间和温度等因素对共轭亚油酸钠分子自交联程度的影响,并采用TEM技术直观表征所获自交联组装体的形貌。结果表明,以过硫酸铵为引发剂,80℃下使pH=13的共轭亚油酸钠水溶液交联反应10 h可以得到平均粒径为20 nm的球状自交联胶束,这是一种潜在的稳定性纳米药物载体或微反应器。
Using high purity natural linoleic acid as raw material, an anionic polymerizable lipid-conjugated linoleic acid sodium salt was prepared by base-catalyzed isomerization reaction. Self-assembling sodium conjugated linoleate into spherical micelles in an aqueous solution and then initiating an inter-molecular self-crosslinking reaction of conjugated linoleic acid inside the micelles via a free radical initiator to finally obtain sodium conjugated linoleate Spherical self-crosslinking micelles. The effects of initiator type and amount, reaction time and temperature on the self-crosslinking degree of conjugated linoleic acid molecules were explored. The morphologies of self-crosslinked assemblies obtained by TEM were characterized visually. The results showed that the spherical self-crosslinked micelles with average particle size of 20 nm could be obtained by cross-linking reaction of sodium conjugated linoleate solution with pH = 13 at 80 ℃ for 10 h with ammonium persulfate as initiator. Potential stability Nanopharmaceutical carriers or microreactors.