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目的:通过对高血压患者血小板P-选择素(CD62P)百分率及血清C-反应蛋白(CRP)的检测,探讨CD62P及CRP在高血压颈动脉粥样硬化(CAS)中的意义。方法:采用流式细胞术和免疫比浊法检测高血压组及对照组的CD62P及CRP,结合超声检查颈动脉内膜-中膜厚度(I MT),进行对比研究。结果:高血压组CD62P阳性百分率及血清CRP分别为(24.56±10.63)%和(4.02±1.83)mg/L,明显高于对照组(P<0·01,P<0·05),高血压I MT增高亚组的CD62P阳性百分率、血清CRP亦高于I MT正常亚组(P<0·01,P<0·05),且颈动脉I MT与CD62P、CRP正相关。结论:CD62P、CRP与高血压CAS严重程度相关,可作为评价高血压动脉粥样硬化的良好指标。
Objective: To explore the significance of CD62P and CRP in the hypertensive patients with carotid atherosclerosis (CAS) by detecting the percentage of platelet P-selectin (CD62P) and serum C-reactive protein (CRP) Methods: CD62P and CRP in hypertension group and control group were detected by flow cytometry and immunoturbidimetry, and carotid arterial intima - media thickness (I MT) was examined by contrast ultrasonography. Results: The positive percentage of CD62P and serum CRP in hypertension group were (24.56 ± 10.63)% and (4.02 ± 1.83) mg / L respectively, which were significantly higher than those in control group (P <0.01 or P <0.05) The positive percentage of CD62P in the subgroup of I MT increased and CRP in serum was also higher than that of the normal subgroup of I MT (P <0.01, P <0.05). The I MT of carotid artery was positively correlated with CD62P and CRP. Conclusion: CD62P and CRP are correlated with the severity of hypertension and can be used as a good indicator to evaluate atherosclerosis in hypertension.