发现青霉素已有50年了,20世纪40年代初牛津Florey学院认识青霉素的化疗前景也已过去了40多年了.自第二次世界大战后期至今,因商业利润和科学的意义,投入开发β-内酰胺类抗生素的资金是巨额的,然而也给予人类以有巨大化疗价值的一系列的抗细菌药物.这里综述以往发现新β-内酰胺类抗生素的某些途径,并指出如何将这些化合物变为可用于临床治疗细菌性感染的新药物.一 It has been 50 years since penicillin was discovered. More than 40 years have passed since the early 1940’s when Florey College of Oxford recognized the prospect of penicillin chemotherapy. Since the late World War II, commercial profits and scientific significance have led to the development of β- Lactam antibiotics have huge amounts of money, but they also give human beings a range of anti-bacterial drugs with great chemotherapeutic value. Here we review some of the ways we discovered new β-lactam antibiotics in the past and pointed out how to turn these compounds into As a new drug for clinical treatment of bacterial infections