食源性微生物的抗生素敏感性和消毒剂耐受性对食品安全和人类健康造成了巨大威胁,它直接或间接地导致了抗生素和消毒剂在治疗或消灭细菌的失败。该文综述了抗生素的多重耐药、消毒剂抗性机制及检测方法以及抗生素和消毒剂交叉耐药机制。未来的研究方向应该着重于对抗生素和消毒剂的使用提供专业指导以及研发出一套综合全面的分子生物学检测方法。 The antibiotic susceptibility and disinfectant resistance of food-borne microorganisms pose a significant threat to food safety and human health, which directly or indirectly leads to the failure of antibiotics and disinfectants in the treatment or elimination of bacteria. This article reviewed the multi-drug resistance of antibiotics, disinfectant resistance mechanisms and detection methods and antibiotic and disinfectant cross-resistance mechanism. Future research directions should focus on providing expert guidance on the use of antibiotics and disinfectants and developing a comprehensive set of molecular biology tests.