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目的探讨体检人群血尿酸(SUA)水平与肱踝脉搏波传导速度(ba-PWV)之间的关系。方法选择2009年10月—2011年12月来我院体检的健康体检者3 127例为研究对象,其中男2 095例、女1 032例;年龄35～64岁。测量身高、体质量、血压;检测空腹SUA、血糖、血脂和ba-PWV。以受检者ba-PWV值<1 400 cm/s为正常,1 400～1 599 cm/s为轻度增快,1 600～1 799 cm/s为中度增快,≥1 800 cm/s为重度增快,对比不同ba-PWV组人群的SUA水平。以SUA水平男性≥420μmol/L、女性≥350μmol/L定为高尿酸血症(HUA),比较各组HUA检出率。将SUA水平与ba-PWV进行相关性分析;采用多因素逐步回归分析评价ba-PWV的影响因素。结果 ba-PWV正常组、轻度增快组、中度增快组和重度增快组的SUA水平分别为(360.7±100.1)、(394.0±97.5)、(390.4±100.1)和(414.0±118.9)μmol/L,4组间SUA水平差异有统计学意义(F=30.514,P=0.000)。男性SUA水平为(412.6±91.7)μmol/L,高于女性的(294.6±70.0)μmol/L(P=0.000)。各ba-PWV组中的男性SUA水平均高于女性(P<0.05)。4组受检者HUA的检出率分别为30.6%、40.9%、41.0%和53.1%,差异有统计学意义(P=0.000)。男性HUA检出率(43.7%)高于女性(17.2%,P=0.000)。男性SUA水平与ba-PWV无线性相关性(r=0.043,P>0.05);女性SUA水平与ba-PWV呈正相关(r=0.248,P<0.05)。以年龄、身高、体质量、收缩压、舒张压、空腹血糖、SUA、总胆固醇(TC)、三酰甘油(TG)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)、肌酐水平为自变量,以ba-PWV为因变量进行多因素逐步回归分析,结果显示收缩压、年龄、空腹血糖、SUA、体质量、TG、肌酐对ba-PWV的影响有统计学意义(P<0.05)。结论成年人尤其是成年女性SUA水平增高与ba-PWV增快相关,对存在心血管疾病及其危险因素的成人应重视SUA和ba-PWV的检测。
Objective To investigate the relationship between serum uric acid (SUA) level and brachial-ankle pulse wave velocity (ba-PWV) in physical examination. Methods A total of 3 127 healthy physical examinations from October 2009 to December 2011 in our hospital were selected as study subjects, including 2 095 males and 1 032 females, aged 35-64 years. Height, body weight and blood pressure were measured. Fasting SUA, blood glucose, lipids and ba-PWV were measured. The results showed that the ba-PWV values of <1 400 cm / s were normal, the slight increase of 1 400 ~ 1 599 cm / s, the moderate increase of 1 600 ~ 1 799 cm / s, s is significantly increased, comparing SUA levels in different ba-PWV groups. SUA level of male ≥ 420μmol / L, female ≥ 350μmol / L as hyperuricemia (HUA), compared the detection rate of HUA in each group. The correlation between SUA level and ba-PWV was analyzed. The influencing factors of ba-PWV were evaluated by multi-factor stepwise regression analysis. Results The levels of SUA in the ba-PWV normal group, mild increase group, moderate increase group and severe increase group were (360.7 ± 100.1), (394.0 ± 97.5), (390.4 ± 100.1) and (414.0 ± 118.9 ) μmol / L, there was significant difference in SUA level between the four groups (F = 30.514, P = 0.000). The level of SUA in male was (412.6 ± 91.7) μmol / L, higher than that in female (294.6 ± 70.0) μmol / L (P = 0.000). The SUA level of males in each ba-PWV group was higher than that of females (P <0.05). The detection rates of HUA in 4 groups were 30.6%, 40.9%, 41.0% and 53.1%, respectively, with significant difference (P = 0.000). The detection rate of HUA in male was higher than that in female (43.7%) (17.2%, P = 0.000). There was no linear correlation between SUA level and ba-PWV (r = 0.043, P> 0.05). There was a positive correlation between female SUA level and ba-PWV (r = 0.248, P <0.05). The effects of different doses of SBP on SUA, TC, TG, HDL-C, LDL-C were investigated with age, height, body weight, systolic blood pressure, diastolic blood pressure, C), creatinine as independent variables, and ba-PWV as the dependent variable by stepwise regression analysis. The results showed that systolic blood pressure, age, fasting blood glucose, SUA, body weight, TG and creatinine had statistical significance Significance (P <0.05). Conclusions The elevation of SUA in adults, especially in adult women, is associated with the rapid increase of ba-PWV. The detection of SUA and ba-PWV should be emphasized in adults with cardiovascular diseases and their risk factors.