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目的比较不同水化方式预防心功能不全患者冠脉介入术后出现对比剂肾病(CIN)的疗效。方法 42例冠心病伴心功能不全的患者随机分为半渗水化组和等渗水化组,分别从冠脉介入术前6h至术后6h予半渗(0.9%生理盐水和5%葡萄糖液等量混合)和等渗(0.9%生理盐水)两种方式行水化治疗,监测血清肌酐(SCr)和计算估计肾小球滤过率(eGFR)。结果两组患者术后SCr和eGFR比较无统计学差异(P>0.05)。两组出现CIN的发病率比较无统计学差异(P>0.05)。结论对于心功能不全的患者,半渗与等渗盐水两种水化方式预防出现CIN的效果相当。
Objective To compare the efficacy of different hydration modes in preventing contrast-induced nephropathy (CIN) after percutaneous coronary intervention in patients with cardiac insufficiency. Methods Forty-two patients with coronary heart disease and cardiac dysfunction were randomly divided into semi-permeable group and isotonic hydration group, which were given semi-osmotic (0.9% saline and 5% glucose solution, respectively) from 6h before PCI to 6h after PCI Volume mixing) and isotonic (0.9% saline), monitoring serum creatinine (SCr) and calculating estimated glomerular filtration rate (eGFR). Results There was no significant difference in postoperative SCr and eGFR between the two groups (P> 0.05). There was no significant difference in the incidence of CIN between the two groups (P> 0.05). Conclusions For patients with cardiac insufficiency, the two hydration modes of semi-permeable and isotonic saline are quite effective in preventing CIN.