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目的了解台州地区儿童呼吸道感染非典型病原体的检出状况,为临床抗感染治疗提供依据。方法采用间接免疫荧光法,检测嗜肺军团菌、肺炎支原体、Q热立克次体、肺炎衣原体、腺病毒、呼吸道合胞病毒、甲型流感病毒、乙型流感病毒、副流感病毒1、2和3型的IgM抗体。结果 2427份标本中,9种常见非典型病原体抗体(IgM)均有检出,总阳性率为33.9%;以MP最为常见,检出率为24.2%。混合感染112例,占13.6%。非典型病原体感染以冬季最高,其次是秋季。≤3岁组检测阳性率最高(65.3%)。结论间接免疫荧光法检测IgM抗体简便、快速,适合临床快速诊断。肺炎支原体是台州地区儿童呼吸道感染的主要病原体;≤3岁组非典型病原体感染率最高,在呼吸道感染高发的秋冬季节,应加强防范。
Objective To understand the detection of atypical pathogens in children with respiratory tract infection in Taizhou and provide the basis for clinical anti-infection treatment. Methods Indirect immunofluorescence assay was used to detect Legionella pneumophila, Mycoplasma pneumoniae, Q fever, Chlamydia pneumoniae, adenovirus, respiratory syncytial virus, influenza A, influenza B, parainfluenza virus 1, 2 And type 3 IgM antibodies. Results Among the 2427 samples, 9 kinds of common atypical antigens (IgM) were detected. The positive rate was 33.9%. The most common was MP. The detection rate was 24.2%. Mixed infection in 112 cases, accounting for 13.6%. Atypical pathogen infection highest in winter, followed by autumn. ≤ 3-year-old group the highest positive rate (65.3%). Conclusion Indirect immunofluorescence assay for IgM antibody is simple, rapid and suitable for rapid clinical diagnosis. Mycoplasma pneumoniae is the main pathogen of respiratory tract infection in children in Taizhou area; the highest infection rate of atypical pathogens in ≤3 years old group should be strengthened in autumn and winter when the respiratory tract infection is high.