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目的通过对复苏周期不同年龄段的单囊胚移植和双囊胚移植的妊娠率、种植率及多胎率的统计分析,探索单囊胚移植的可行性。方法以本中心2012年的1367个囊胚复苏周期作为研究对象,将其分为单囊胚移植和双囊胚移植两组,每组按不同年龄分为A组(小于35岁组)、B组(35-38岁组)和C组(大于等于38岁组)。分别对其妊娠率、种植率及多胎率进行比较分析。结果 A组和C组单囊胚移植的妊娠率(51.52%,32.65%)显著低于双囊胚移植(62.73%,50.65%),而B组的单囊胚移植的妊娠率(48.39%)略低于双囊胚移植(56.84%),无显著差异;三个年龄组单囊胚移植率(44.51%,41.94%,24.49%)略高于双囊胚移植的种植率(38.79%,31.05%,22.73%),无显著差异;单囊胚移植的多胎仅发生在A组(2.96%),都显著低于双囊胚移植组(23.34%,29.63%,15.38%),而双囊胚移植的多胎率在B组最高,C组最低,无显著差异。结论冷冻复苏周期,小于38岁的患者可以选择性单囊胚移植,而对于38岁以上的患者建议双囊胚移植。
OBJECTIVE: To investigate the feasibility of single blastocyst transplantation by statistical analysis of pregnancy rate, implantation rate and multiple birth rate of single blastocyst and double blastocyst in different ages of resuscitation cycle. Methods The 1367 blastocyst resuscitation cycles of our center in 2012 were divided into two groups: single blastocyst transplantation and double blastocyst transplantation. Each group was divided into A group (less than 35 years old group), B (35-38 years old) and C (38 years old or older). Their pregnancy rates, implantation rates and multiple birth rates were compared. Results The pregnancy rates (51.52%, 32.65%) of single blastocyst transplantation in group A and group C were significantly lower than those in double blastocyst transplantation (62.73%, 50.65%), while those in group B were 48.39% Which was slightly lower than that of double blastocyst transplantation (56.84%). The single blastocyst rates in three age groups (44.51%, 41.94%, 24.49%) were slightly higher than those in double blastocyst transplantation (38.79%, 31.05 %, 22.73% respectively). There was no significant difference between the two groups (P <0.05) Transplantation of multiple birth rate in the highest B group, C lowest, no significant difference. Conclusion In patients with frozen-thawed cycles less than 38 years old, selective single blastocyst transplantation can be performed, while double-blastocyst transplantation is recommended in patients over 38 years of age.