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目的分析2型糖尿病发生慢性肾脏疾病(CKD)的危险因素。方法回顾性分析733例2型糖尿病住院患者的病例资料,根据检查结果将患者分为未合并CKD与合并CKD两组,对其一般资料和相关检查结果进行对比。CKD危险因素采用非条件Logistic回归分析。结果 733例患者中,212例合并CKD,发生率为28.9%。与未合并CKD组患者比较,合并CKD组患者的糖尿病病程更长,视网膜病变和吸烟者比例更高,体质量指数(BMI)、收缩压、血肌酐、血尿酸、低密度脂蛋白胆固醇(LDL-C)与24 h尿白蛋白水平更高,肾小球滤过率更低,差异有统计学意义(P<0.05)。经多因素Logistic回归分析显示,BMI、糖尿病病程、收缩压、血尿酸、LDL-C及吸烟与2型糖尿病发生CKD独立相关。结论 2型糖尿病患者发生CKD与多种临床危险因素相关,戒烟、控制血压和体质量、降低血尿酸和LDL-C水平,对延缓2型糖尿病患者发生CKD有益。
Objective To analyze the risk factors of chronic kidney disease (CKD) in type 2 diabetic patients. Methods The data of 733 inpatients with type 2 diabetes mellitus were retrospectively analyzed. According to the results of the examination, the patients were divided into two groups: CKD without CKD and CKD. The general data and the related test results were compared. CKD risk factors using unconditional Logistic regression analysis. Results Of the 733 patients, 212 had CKD, with a rate of 28.9%. Patients with CKD had longer duration of diabetes, a higher proportion of retinopathy and smokers, and higher body mass index (BMI), systolic blood pressure, serum creatinine, serum uric acid, and low density lipoprotein cholesterol (LDL) -C) with 24 h urinary albumin levels, glomerular filtration rate was lower, the difference was statistically significant (P <0.05). Multivariate Logistic regression analysis showed that BMI, diabetes duration, systolic blood pressure, serum uric acid, LDL-C and smoking were independently associated with type 2 diabetes CKD. Conclusions The occurrence of CKD in type 2 diabetic patients is associated with many clinical risk factors, and smoking cessation, blood pressure and body weight control, and lowering serum uric acid and LDL-C levels are beneficial for delaying the onset of CKD in type 2 diabetic patients.