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目的探讨坦索罗辛对肾输尿管结石体外冲击波碎石(ESWL)后结石排空和石街的影响。方法80例肾或输尿管单发结石患者行ESWL后分为两组:对照组38例,每天口服左氧氟沙星0.5 g,共7 d;研究组42例,每日加服坦索罗辛0.4 mg。以治疗满30 d或结石排出为观察终点。观察结石排空率、排空时间、止痛药使用以及石街情况。结果研究组总结石排空率高于对照组(92.5%vs.81.6%)、排空时间短于对照组[(5.8±2.7)d v.s(9.7±3.5)d](P<0.05)。研究组需手术干预的石街占11.1%(1/9),而对照组为42.9%(3/7)(P<0.05)。结论坦索罗辛能促进肾输尿管结石ESWL治疗后的排出,尤其是大结石,并且有利于石街的自行排出。
Objective To investigate the effect of tamsulosin on stone emptying and stone street after ESWL in renal ureteral calculi. Methods Eighty patients with renal or ureteral calculi underwent ESWL and divided into two groups: control group (n = 38) and levofloxacin (n = 0.5) for 7 days. Study group (n = 42) received tamsulosin 0.4 mg daily. Treatment of 30 d or stones discharged as the end point of observation. Observation of stone emptying rate, emptying time, the use of painkillers and Stone Street situation. Results The total emptying rate of the study group was higher than that of the control group (92.5% vs.81.6%), and the emptying time was shorter than that of the control group [(5.8 ± 2.7) days vs 9.7 ± 3.5 days] (P <0.05). There were 11.1% (1/9) of the stone blocks in the study group undergoing surgical intervention, compared with 42.9% (3/7) in the control group (P <0.05). Conclusion Tamsulosin can promote the excretion of renal ureteral calculi ESWL after treatment, especially for large stones, and is conducive to the self-discharge of stone street.