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应用免疫组织化学和显微图像分析方法，对１６ 只哮喘豚鼠Ｃ７～Ｔ５ 节段脊髓后角内的ＣＧＲＰ免疫反应产物进行了定量研究。结果表明，哮喘豚鼠Ｃ７～Ｔ５ 节段脊髓后角内ＣＧＲＰ阳性反应纤维的密度大大高于正常对照组和实验对照组（Ｐ＜ ０．０１），平均灰度值明显低于正常对照组和实验对照组（Ｐ＜ ０．０１）。本研究结果提示，Ｃ７ ～Ｔ５ 节段脊髓后角内的ＣＧＲＰ可能参与支气管哮喘发病的病理生理过程。本实验结果为进一步探讨哮喘发病的中枢机制提供了一定的形态学依据。
Immunohistochemistry and microscopic image analysis methods were used to quantitatively study the CGRP immunoreactivity in the posterior horn of C7 ~ T5 segments in the asthmatic guinea pigs. The results showed that the density of CGRP-positive fibers in the posterior horn of C7 ~ T5 segment in asthmatic guinea pigs was significantly higher than that in normal control group and experimental control group (P <0.01), and the mean gray value was significantly lower than that in normal control group and experimental group Control group (P <0.01). Our results suggest that CGRP may play a role in the pathogenesis of bronchial asthma in C7 ~ T5 spinal dorsal horn. The results of this study provide some morphological evidence for further exploration of the central mechanism of asthma pathogenesis.