目的评价窝沟封闭对第一恒磨牙的防龋效果。方法对50例儿童六龄齿进行窝沟封闭治疗,定期随访评价其防龋效果。结果封闭60个月后,窝沟封闭牙齿患龋率10%,而对侧未封闭牙齿患龋率为30%,差异有统计学意义(P<0.05)。结论窝沟封闭是预防龋齿的有效措施之一,防止封闭剂脱落是保证治疗成功的关键。 Objective To evaluate the anticaries effect of pit and fissure sealant on the first permanent molars. Methods Fifty pediatric six-year-old teeth were treated by pit and fissure sealant, and their anticaries effect was evaluated regularly. Results After 60 months of occlusion, the caries occured in pit and fissure dentition was 10%, while the caries prevalence in uncoated side contralateral was 30% (P <0.05). Conclusion The pit and fissure sealant is one of the effective measures to prevent dental caries. To prevent the sealant from falling off is the key to the successful treatment.