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目的探讨地佐辛对无痛人流术麻醉及其术后镇痛的效果及安全性。方法 ASAI级无痛人工流产术患者240例,随机均分为:B组(单纯丙泊酚组)、D组(丙泊酚+地佐辛)。记录用药前、术中2min、术毕时的收缩压(SBP)、HR、SpO2,观察术毕意识恢复时间、丙泊酚总用量、术中肢动情况及呼吸抑制情况,术毕清醒后30min采用视觉模拟评分(VAS评分)判定下腹部疼痛的程度。结果与B组相比,术中D组SBP、HR、SpO2变化较稳定,有差异(P<0.05);D组丙泊酚总用量、术中发生呼吸抑制和肢动例数均低于B组,术毕30min下腹痛VAS评分D组也低于B组,有明显差异(P<0.05)。结论在人工流产术中地佐辛联合丙泊酚具有良好的术中麻醉及术后镇痛效果,对呼吸及循环抑制较轻,是一种较为安全有效的配伍方法。
Objective To investigate the effect and safety of dezocine on painless abortion anesthesia and postoperative analgesia. Methods A total of 240 ASAI painless induced abortion patients were randomly divided into two groups: group B (propofol only) and group D (propofol + dezocine). The systolic blood pressure (SBP), HR, SpO2 at the end of surgery, the recovery time of conscious consciousness, total propofol consumption, intraoperative limb movements and respiratory depression were recorded before treatment and 2 minutes after operation, and 30 minutes after awake Visual analogue scale (VAS score) was used to determine the extent of lower abdominal pain. Results Compared with group B, the changes of SBP, HR and SpO2 in group D were more stable than those in group B (P <0.05). The total dosage of propofol, intraoperative respiratory depression and the number of extremity movements in group D were lower than those in group B Group, 30min after surgery under abdominal pain VAS score D group is also lower than the B group, there was a significant difference (P <0.05). Conclusion In artificial abortion, dezocine combined with propofol has good intraoperative anesthesia and postoperative analgesia, and less inhibition of respiration and circulation, which is a safe and effective method of compatibility.