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原发性血小板增多症(ET)是一种少见的慢性骨髓增殖性疾病,同胞兄妹发病则更为罕见.本文报告姊妹同患ET2例,并用DNA技术对其克隆性进行了研究.例1为56岁女性,在作子宫切除术时首次发现其血小板及白细胞增高.2年后骨髓活检示髓细胞、红细胞及异常巨核细胞高度增生,符合ET的标准.4年后转变为真性红细胞增多症.例2为例子之姐
Essential thrombocythemia (ET) is a rare chronic myeloproliferative disease, siblings are more common in the incidence of siblings.This article reports the same sisters with patients with ET2 cases, and its clonality was studied using DNA technology.Example 1 The 56-year-old woman was the first to find an increase in platelets and leukocytes during a hysterectomy.2 years after the bone marrow biopsy showed hyperplasia of myeloid, erythrocytes and abnormal megakaryocytes, which met the criteria of ET and became polycythemia 4 years later. Example 2 as an example sister