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砷是重要的环境污染物和生产性毒物,饮水型砷中毒和燃煤污染型砷中毒是危害较严重的公共卫生问题,而职业性砷接触可引起接触者急性和慢性砷中毒,甚至导致职业性肿瘤。砷及其化合物的致癌作用机制包括氧化应激、基因突变和染色体畸变等。但最近的研究表明,表观遗传学作用也是砷致癌作用的重要机制[1]。表观遗传学是指研究不涉及遗传物质核苷酸序列的改变,但可以通过有丝分裂和减数分裂实现代间传递(遗传)的生物现象的遗传学分支领域[2]。
Arsenic is an important environmental pollutant and productive poison. Drinking arsenic poisoning and coal-burning arsenic poisoning are more serious public health problems. Occupational arsenic exposure can cause acute and chronic arsenic poisoning in contact persons and even lead to occupations Sexual cancer. Arsenic and its compounds oncogenic mechanisms include oxidative stress, gene mutations and chromosomal aberrations. However, recent studies have shown that epigenetic effects are also important mechanisms of arsenic carcinogenesis [1]. Epigenetics refers to the field of genetics that studies biological phenomena that do not involve changes in the nucleotide sequence of a genetic material, but which can be transmitted (mitogenically) through mitosis and meiosis [2].