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目的:掌握中西结合的方法,提高癌性腹水的控制率。方法:腹腔内灌注给药。卵巢癌:DDP(顺铂)60～100mg,足叶乙甙(VP_(16))200～300mg;消化道腺癌,顺铂(DDP):60～100mg,5—氟脲嘧啶(5—Fu)500～1000mg。每两周一次,6次为一疗程,化疗期间联合中药:参苓地龙汤,日服1剂,并给予常规水化,利尿止痛,止呕等对症处理。结果:按照肿瘤近期疗效标准,腹水完全缓解18例,显效有效11例,无效17例。中位缓解期8月。结论:①体质较差、率龄偏高的患者也能够耐受化疗。②腹腔内给药的高浓度更有利于控制,消除腹水,有效防止肝转移,且全身毒副作用轻。③中药的联合应用,使化疗毒副作用减轻,防止肝损害及骨髓抑制,患者痛苦小,疗效高。④长期生存的结果有待于病例数的增多和长期随访。
Objective: To master the combination of Chinese and Western methods and improve the control rate of cancerous ascites. Methods: Intraperitoneal infusion administration. Ovarian cancer: 60-100 mg of DDP (cisplatin), 200-300 mg of acetylcholine (VP 16); gastrointestinal cancer, cisplatin (DDP): 60-100 mg, 5-fluorouracil (5-Fu ) 500 to 1000 mg. Once every two weeks, 6 times for a course of treatment, combined with traditional Chinese medicine during chemotherapy: Shen Qi Di Long Tang, a day service, and given conventional hydration, diuretic pain, vomiting and other symptomatic treatment. Results: According to the standard of short-term efficacy of the tumor, 18 cases of ascites were completely relieved, 11 cases were markedly effective, and 17 cases were ineffective. The median remission period is August. Conclusion: 1 Patients with poor constitution and high age can also tolerate chemotherapy. 2 The high concentration of intraperitoneal administration is more conducive to control, eliminate ascites, and effectively prevent liver metastases, and the systemic side effects are light. 3 The combined use of traditional Chinese medicine reduces the toxic and side effects of chemotherapy, prevents liver damage and bone marrow suppression, and patients have little pain and high efficacy. 4 The long-term survival results need to increase the number of cases and long-term follow-up.