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通过家系调查探讨卵巢癌家族聚集情况及高危病人的防治。方法：由卵巢癌患者及其直系亲属完成其家族中卵巢癌及其他恶性肿瘤，特别是乳腺癌、非息肉性结直肠癌、子宫内膜癌等的登记，以上所有肿瘤的诊断均经病理证实。结果：１９７４年１月至１９９６年６月住院的原发卵巢癌患者２８２例，其中１１例符合遗传性卵巢癌综合征，阳性家族史３．９％，平均发病年龄４８．６岁。按遗传性卵巢癌综合征分类：特异位点性卵巢癌２例，卵巢癌或乳腺癌综合征４例，ＬｙｎｃｈⅡ综合征５例。结论：对属于家族性卵巢癌家系中的妇女应及早定期随访和监测，以便对高危人群的发病及早做出诊断
Family investigations were conducted to investigate the clustering of ovarian cancer and the prevention and treatment of high-risk patients. METHODS: Ovarian cancer patients and their immediate family members completed the registration of ovarian cancer and other malignant tumors in their family, especially breast cancer, non-polyposis colorectal cancer, and endometrial cancer. All the above tumors were diagnosed by pathology. . RESULTS: A total of 282 cases of primary ovarian cancer were hospitalized from January 1974 to June 1996. Eleven of them were in accordance with the hereditary ovarian cancer syndrome. The positive family history was 3.9%. The average age of onset was 48.6 years. According to the hereditary ovarian cancer syndrome, there were 2 cases of specific ovarian cancer, 4 cases of ovarian cancer or breast cancer syndrome, and 5 cases of Lynch II syndrome. Conclusion: Women who are members of a familial ovarian cancer family should be followed up and monitored early, so that early diagnosis of the onset of high-risk groups can be made.