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目的了解肝硬化患者的肠道内各类菌群及其消长状况,探讨血浆内的毒素水平和肠道细菌的关联。方法选取本院收治的肝硬化患者60例作为观察组,并选取正常健康者60例,将其粪便中的常见菌群进行定量分析,采用偶氮显色基质法进行外周血内毒素水平的检测,并观察其差异和相关性。结果对照组患者粪便菌群中的厌氧菌数明显高于肝硬化组,且肝硬化组患者厌氧菌中的双歧杆菌、真杆菌和拟杆菌的检出率也高于对照组,两组数据对比差异有统计学意义(P<0.05)。此外,肝硬化患者的血内毒素水平要明显高于对照组(P<0.05),且大肠杆菌在各组数量越大,则其血内毒素水平越高,二者具有明显的相关性。结论肝硬化患者均存在肠道菌群失调的现象,最典型的就是需氧菌的增多和厌氧菌的减少。患者大肠杆菌量和内毒素水平存在一定的相关性,可能是导致肝硬化内毒素血症的影响因子。
Objective To understand the intestinal flora of patients with cirrhosis and its growth and decline, to explore the relationship between plasma toxins and intestinal bacteria. Methods Sixty patients with cirrhosis in our hospital were selected as the observation group and 60 normal controls were selected. The common bacteria in the stool samples were quantitatively analyzed, and the azo chromogenic matrix method was used to detect the level of endotoxin in the peripheral blood , And observe the differences and correlations. Results The number of anaerobic bacteria in the fecal flora in the control group was significantly higher than that in the cirrhosis group. The detection rates of bifidobacteria, eubacteria and bacteroides in the anaerobic bacteria in the cirrhosis group were also higher than those in the control group. There was significant difference between the two groups (P <0.05). In addition, the level of serum endotoxin in patients with cirrhosis was significantly higher than that in the control group (P <0.05). The greater the number of E. coli in each group, the higher the level of blood toxin, and the two had obvious correlation. Conclusions All patients with liver cirrhosis have intestinal flora imbalance, the most typical is the increase of aerobic bacteria and the reduction of anaerobic bacteria. There is a certain correlation between the amount of E. coli and the level of endotoxin in patients, which may be the influencing factor of endotoxemia in cirrhosis.