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目的:探讨年轻女性在接受反复控制性卵巢刺激(COS)-IVF/ICSI治疗对卵巢储备功能及其反应性的变化。方法:回顾性分析连续3次接受COS-IVF/ICSI-ET治疗周期的<35周岁的不孕症患者,分析比较其实验室指标和临床结局。结果:共纳入129例不孕症患者的387个周期。患者3个COS-IVF/ICSI治疗周期间月经第3日的基础卵泡刺激素(basal follicle-stimulating hormone,bFSH)、窦卵泡计数(antral follicle count,AFC)、促排卵天数、hCG注射日E2峰值、获卵数、正常受精率及优质胚胎率均无统计学差异(P>0.05);第2次和第3次治疗周期使用促性腺激素(gonadotropin,Gn)剂量明显高于第1次治疗,差异具有统计学意义(P<0.05)。结论:<35周岁重复COS-IVF/ICSI周期对卵巢储备功能无影响,对其卵巢反应性有一定影响。
Objective: To investigate the changes of ovarian reserve and reactivity in young women undergoing repeated controlled ovarian stimulation (COS) -IVF / ICSI treatment. Methods: We retrospectively analyzed 3-year-old infertility patients who underwent 3 consecutive cycles of COS-IVF / ICSI-ET and analyzed their laboratory parameters and clinical outcomes. Results: A total of 129 cycles of infertility were enrolled in 129 cycles. The basal follicle-stimulating hormone (bFSH), antral follicle count (AFC), ovulation induction days, E2 peak on the day of hCG injection on the third day of menstruation during the three COS-IVF / (P> 0.05). The dosage of gonadotropin (Gn) in the second and third treatment cycles was significantly higher than that of the first treatment, The difference was statistically significant (P <0.05). CONCLUSIONS: Repeated COS-IVF / ICSI cycles <35 years of age have no effect on ovarian reserve and have some effect on their ovarian response.