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目的:观察α-烯醇化酶(ENO1)在鼻咽癌中的表达状态,探讨其与鼻咽癌的发生发展及转移的关系。方法:采用SP免疫组织化学方法检测120例鼻咽癌初治患者癌组织中ENO1表达。结果:鼻咽癌组织中ENO1蛋白高表达率为60.0%(72/120),鼻咽黏膜炎性组织为27.5%(11/40),两组差异有统计学意义(P<0.05)。T1、T2、T3期患者ENO1蛋白表达阳性率均高于T4患者,其差异有统计学意义(χ2=11.424,P<0.05)。但ENO1蛋白表达与颈淋巴结转移及放疗后复发和转移无关(P>0.05)。结论:ENO1蛋白的高表达可能涉及鼻咽癌的发生和发展过程。
OBJECTIVE: To observe the expression of α-enolase (ENO1) in nasopharyngeal carcinoma (NPC) and to investigate the relationship between ENO1 expression and the development and metastasis of NPC. Methods: SP immunohistochemistry was used to detect ENO1 expression in 120 cases of nasopharyngeal carcinoma patients. Results: The high expression rate of ENO1 protein in nasopharyngeal carcinoma was 60.0% (72/120) and that in nasopharyngeal mucosa was 27.5% (11/40). The difference between the two groups was statistically significant (P <0.05). The positive rates of ENO1 protein expression in T1, T2 and T3 were higher than those in T4, the difference was statistically significant (χ2 = 11.424, P <0.05). However, the expression of ENO1 protein had no correlation with cervical lymph node metastasis and recurrence and metastasis after radiotherapy (P> 0.05). Conclusion: The overexpression of ENO1 protein may be involved in the occurrence and development of nasopharyngeal carcinoma.