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5年来,作者采用苯妥英钠治疗局限性线状硬皮病5例。剂量100毫克,开始时,每日2～3次,病情改善后每日1次,5例病人中,除1例治疗时间短略有进步外,其余病人在经过1年半至5年治疗,均显示显著进步。皮损明显变软,肢体运动功能得到显著恢复。本病的自然病程尚未完全明了,但可能自发缓解。但此5例病人:①用苯妥英钠治疗2～3个月后均得到一致的早期治疗效果。②部分病人过早停止治疗可复发。③病期已1～16年,没有过明显的自发性缓解。因此可说明病情的改善是苯妥
For 5 years, the authors used phenytoin in the treatment of localized scleroderma in 5 cases. Dose 100 mg, at the beginning, 2 to 3 times a day, 1 day after the condition improved, 5 patients, except for a short treatment time slightly improved, the remaining patients after 1 year and a half to 5 years of treatment, All showed significant improvement. Skin lesions significantly softened, limb motor function was significantly recovered. The natural course of the disease is not yet fully understood, but may spontaneously alleviate. However, these 5 patients: ① with phenytoin sodium treatment for 2 to 3 months have been the same early treatment. ② some patients premature termination of treatment can relapse. ③ disease has been 1 to 16 years, there was no significant spontaneous remission. So can explain the improvement of the condition is phenytoin