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目的:探讨在早期采用S100B蛋白和NSE在判断新生儿时期胆红素脑损伤方面的临床意义。方法:分析2012年2月至2013年8月100例在我院接受治疗的高胆红素血症患儿的临床资料,并选取不伴有黄疸的正常足月新生儿80例作为对照组。比较观察组和对照组新生儿的一般资料、TSB、NSE、S100B水平差异,以及BAEP正常组与异常组新生儿的TSB、NSE、S100B水平差异,并对观察组患儿的TSB与NSE、S100B行相关性分析。结果:本研究共纳入研究对象180例,其中观察组患儿100例,正常新生儿80例。观察组患儿的TSB、NSE、S100B水平均显著高于对照组(P均<0.01);BAEP正常组患儿的NSE(t=6.500,P<0.01)、S100B(t=6.929,P<0.01)水平显著低于BAEP异常组患儿,而TSB无显著性差异(P>0.05);NSE(r=0.563,P=0.012)、S100B(r=0.432,P=0.009)均与TSB呈现明显正相关的关系。结论:S100B蛋白及血清NSE可以作为胆红素脑损伤的早期的敏感指标。
Objective: To explore the clinical significance of early use of S100B protein and NSE in judging neonatal bilirubin brain injury. Methods: The clinical data of 100 children with hyperbilirubinemia treated in our hospital from February 2012 to August 2013 were analyzed. 80 normal newborn infants without jaundice were selected as the control group. The differences of TSB, NSE and S100B levels between the observation group and the control group were statistically analyzed. The differences of TSB, NSE and S100B levels between the normal and abnormal BAEP groups were also observed. The levels of TSB, NSE, S100B Line correlation analysis. Results: A total of 180 subjects were enrolled in this study, including 100 cases of observation group and 80 cases of normal newborns. The levels of TSB, NSE and S100B in the observation group were significantly higher than those in the control group (all P <0.01). The NSE (t = 6.500, P <0.01) and S100B (t = 6.929, ) Were significantly lower than those in the abnormal BAEP group, but no significant difference was found between the TSB group (P> 0.05). NSE (r = 0.563, P = 0.012) and S100B Related relations. Conclusion: S100B protein and serum NSE can be used as early sensitive indicators of bilirubin brain injury.