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目的探讨抗中性粒细胞胞浆抗体(pANCA)、抗酿酒酵母抗体(ASCA)在溃疡性结肠炎(UC)诊断、鉴别诊断中的意义及pANCA与UC活动性的关系。方法采用间接免疫荧光法测定血清pANCA和ASCA水平。结果 pANCA诊断UC的敏感性、特异性分别为62.5%、96.1%,联合监测pANCA+/ASCA-诊断UC的敏感性、特异性分别为52.5%、100%。pANCA阳性率高低与UC活动状态、严重程度、病变范围无关。结论 pAN-CA是UC较特异血清抗体,可用于鉴别UC和克罗恩病(CD)。联合监测pANCA/ASCA可进一步提高诊断UC的特异性。但pANCA与UC活动性、病情轻重程度、病变范围无关。
Objective To investigate the significance of anti-neutrophil cytoplasmic antibody (pANCA) and anti-Saccharomyces cerevisiae antibody (ASCA) in the diagnosis and differential diagnosis of ulcerative colitis (UC) and the relationship between pANCA and UC activity. Methods Serum levels of pANCA and ASCA were measured by indirect immunofluorescence. Results The sensitivity and specificity of pANCA in the diagnosis of UC were 62.5% and 96.1% respectively. The sensitivity and specificity of pANCA + / ASCA-combined diagnosis of UC were 52.5% and 100% respectively. The positive rate of pANCA was not related to the state of UC activity, severity and extent of disease. Conclusions pAN-CA is a specific serum antibody against UC and can be used to identify UC and Crohn’s disease (CD). Joint monitoring of pANCA / ASCA can further improve the specificity of the diagnosis of UC. But pANCA and UC activity, the severity of the disease, the extent of the disease has nothing to do.