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目的 探讨一氧化氮 (NO)、内皮素 (ET)在脑出血患者病程、预后中的病理生理意义。方法 应用硝酸还原酶法、放射免疫法分别检测 35例脑出血患者急性期和恢复期血清NO、血浆ET水平。结果 脑出血患者急性期血清NO水平明显降低、血浆ET - 1水平明显升高 (P <0 .0 1) ;并与病情严重程度相关 ,重型患者血浆ET - 1水平明显高于轻型 (P <0 .0 5 ) ;预后差的患者恢复期血浆ET - 1水平明显高于、血清NO水平明显低于预后好的患者 (P <0 .0 5 )。结论 脑出血后的NO/ET动态平衡破坏参与了疾病的病理生理过程 ,并影响预后
Objective To investigate the pathophysiological significance of nitric oxide (NO) and endothelin (ET) in the course and prognosis of patients with intracerebral hemorrhage. Methods Nitric acid reductase and radioimmunoassay were used to detect serum NO and plasma ET levels in 35 patients with ICH during acute and convalescent periods respectively. Results The levels of serum NO in patients with acute cerebral hemorrhage were significantly lower than those in patients with severe acute cerebral hemorrhage (P <0.01), and correlated with the severity of the disease. The levels of plasma ET - 1 in patients with severe cerebral hemorrhage were significantly higher than those in patients with mild type of cerebral hemorrhage (P < 0. 05). Patients with poor prognosis had significantly higher levels of plasma ET - 1 in convalescent patients and serum NO levels were significantly lower in patients with poor prognosis (P <0.05). Conclusions The dynamic balance of NO / ET after intracerebral hemorrhage is involved in the pathophysiological process of the disease and affects the prognosis