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目的分析医用电离辐射作业女性外周血淋巴细胞姐妹染色单体互换(SCE)对习惯性流产的影响。方法随机选择医用电离辐射作业的习惯性流产女性34人和正常的育龄女性20人,检测其外周血淋巴细胞姐妹染色单体互换,记数SCE发生率。结果观察组的外周血淋巴细胞SCE发生率为7.22±0.88,明显高于对照组(P<0.05)。结论 SCE的发生可作为长期小剂量接触电离辐射作业习惯性流产女性染色体结构稳定性的检测指标。这种辐射作业环境中的某些有害物质对女性DNA损伤有一定的影响,可使机体产生一定的辐射损伤。
Objective To analyze the effect of sister chromatid exchange (SCE) on peripheral blood lymphocytes in women with habitual abortion under medical radiation. Methods 34 randomly selected women with habitual abortion and 20 normal women of childbearing age were enrolled in this study. Their sister chromatid exchange and peripheral blood lymphocyte count were recorded. Results The incidence of SCE in peripheral blood lymphocytes in observation group was 7.22 ± 0.88, which was significantly higher than that in control group (P <0.05). Conclusion The occurrence of SCE can be used as a detection index for the structural stability of chromosomes in habitual abortion women who have been exposed to long-term low-dose exposure to ionizing radiation. Some of these harmful substances in the radiation environment have a certain impact on DNA damage in women and can cause certain radiation damage to the body.