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本文报道3例患者(无肾病史,治疗前肾功能均正常)因高血压服用 dyazide 1～2片/日(每片含双氢氯噻嗪25mg,氨苯喋啶50mg),5～10周后均产生蛋白尿微量～+,沉渣中有多数白细胞。3例均有氮质血症,1例少尿。均经肾穿刺活检确诊为急性间质性肾炎。停药后9天～18个月尿常规及肾功能全部恢复正常。药物引起间质性肾炎肾功能衰竭者已有报道。病人多有发热、皮疹、嗜酸白细胞增多及间质性肾炎,故认为其发病与过敏反应有关。本文3例中有2例嗜
This article reports 3 patients (no history of kidney disease, renal function before treatment were normal) due to hypertension taking dyazide 1 ~ 2 tablets / day (each containing hydrochlorothiazide 25mg, triamterene 50mg), 5 to 10 weeks have produced proteinuria Trace ~ +, sediment in the majority of white blood cells. 3 cases had azotemia, 1 case of oliguria. All were confirmed by renal biopsy as acute interstitial nephritis. After stopping the medicine from 9 days to 18 months, all the urine routine and renal function returned to normal. Drug-induced interstitial nephritis renal failure have been reported. More patients with fever, rash, eosinophilia and interstitial nephritis, so that its incidence and allergic reactions. 2 cases in this article 2 cases addicted