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阐述顺铂腹腔注射的临床药理学基础,说明顺铂腹腔注射后可以提高腹腔内药物的浓度,有利于癌性腹水和残留癌灶的消失。并报道了我科自1984年5月～1986年12月收治的24例(Ⅲ期18例、Ⅳ期6例)晚期卵巢癌病人的治疗情况。全部病例均经手术和病理证实,都进行了腹腔内注射顺铂和肿瘤细胞减灭术,部分病人还作了其他化疗。经随访观察,完全有效率为58.33％,部分有效率为25％,总有效率为83.33％。
Explain the clinical pharmacology of intraperitoneal injection of cisplatin. It shows that intraperitoneal injection of cisplatin can increase the concentration of intraperitoneal drug, which is beneficial to the disappearance of cancerous ascites and residual foci. And reported the treatment of 24 patients with advanced ovarian cancer (18 cases of stage III and 6 cases of stage IV) admitted to our department from May 1984 to December 1986. All cases were confirmed by surgery and pathology. All patients received intraperitoneal injection of cisplatin and cytoreductive surgery. Some patients also performed other chemotherapy. After follow-up observation, the total effective rate was 58.33%, the partial effective rate was 25%, and the total effective rate was 83.33%.