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本文论述药物对化验室试验的干扰的某些机理,并举例说明之。药物干扰试验的机理可分为三种主要类型:1、药物正常药理特性所致的干扰。2、药物对病人的毒性所致的干扰。3、药物妨碍实际试验方法所致的干扰。就第一类而言,这种干扰(如果确是真正的干扰)或许是最易于预见和识别,因为它们反映正常药理作用所致的变化。用噻嗪类利尿药、利尿酸或速尿病人的血清钾浓度降低,或者服用丙磺舒患者尿酸浓度的改变,都是这类干扰中简单的例子。
This article discusses some of the mechanisms by which drugs interfere with laboratory tests and gives examples. The mechanism of drug interference test can be divided into three main types: 1, the interference caused by the normal pharmacological properties of the drug. 2, drugs caused by the toxicity of the patient’s interference. 3, drugs interfere with the interference caused by the actual test method. In the first category, such disturbances (if indeed interference) are perhaps the most predictable and identifiable as they reflect changes due to normal pharmacological effects. Reduced serum potassium levels with thiazide diuretics, uric acid, or furosemide, or changes in uric acid concentrations in patients with probenecid, are simple examples of this type of interference.