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目的探讨冠心病伴中、重度牙周炎患者牙周基础治疗后,牙周状况及血清白介素-1β(IL-1β)和肿瘤坏死因子α(TNF-α)水平的变化。方法选择30名伴有中、重度牙周炎的冠心病患者,比较牙周基础治疗前后的牙周临床指标(龈沟出血指数、探诊深度、临床附着丧失)和血清IL-1β、TNF-α水平。结果牙周基础治疗后,所以患者的牙周临床指标均有好转,血清中IL-1β及TNF-α水平明显降低。结论牙周基础治疗不仅能改善牙周状况,还可降低血清IL-1β和TNF-α和水平,有利于冠心病的预防和治疗。
Objective To investigate the changes of periodontal status, serum levels of interleukin-1β (IL-1β) and tumor necrosis factor-α (TNF-α) in patients with coronary heart disease complicated with moderate and severe periodontitis after periodontal basic treatment. Methods Thirty patients with coronary heart disease accompanied by moderate and severe periodontitis were enrolled in this study. The clinical data of periodontal (gingival sulcus bleeding index, probing depth, clinical attachment loss), serum IL-1β, TNF- α level. Results After periodontal basic treatment, the clinical periodontal index of patients improved, and the levels of IL-1β and TNF-α in serum decreased significantly. Conclusion The basic periodontal treatment can not only improve the periodontal status, but also decrease the level of serum IL-1β and TNF-α, which is propitious to the prevention and treatment of coronary heart disease.